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@idstewardship
📸 I think this might be a nice resource so posting it here for future reference… 🧠 knowing about PBP affinity can help with understanding why in some scenarios dual beta-lactam therapy can be reasonable (which tend to be few and far)… for example when using ceftiaxone + ampicillin for Enterococcal infective endocarditis. Ampicillin has at least some activity versus PBP 1, 4, and 5. Some cephalosporins can add substantially to this including activity versus PBP 2 and 3. The result of the greater overall PBP saturation is thought to produce 💥 more complete inhibition of cell wall synthesis and therefore enhanced bacterial killing! Hazah! 😃 We like dead bugs around here, bc dead bugs can’t cause infections..………….. #PBP #Antibiotics #MechanismOfAction #Pharmlife #Pharmacology #bugsanddrugs
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